Corticosteroids for severe alcoholic hepatitis: what constitutes response?
نویسندگان
چکیده
منابع مشابه
Treatment of severe alcoholic hepatitis with corticosteroids and pentoxifylline.
Despite being themost frequently abused drug for centuries, alcohol was not recognized as a direct hepatotoxin until the 1960s.1 Alcohol abuse accounts for the third leading preventable causeofdeath and the secondmost commoncauseof cirrhosis after hepatitis C virus infection in the United States.2,3 Alcoholichepatitis is a commoncomplicationofalcohol abuse; its severity can range frommild to se...
متن کاملCorticosteroids for alcoholic hepatitis--what's next?
Alcoholic hepatitis (AH) is observed in approximately 20% of heavy drinkers. The treatment of AH remains controversial and will, in the near future, constitute one of the main challenges to clinicians involved in the management of severe alcoholic liver disease [1]. Individual data from the last three randomized controlled trials (RCT), prospective studies and a recent RCT constantly showed tha...
متن کاملInfections in severe alcoholic hepatitis
Severe alcoholic hepatitis (sAH), defined by a modified discriminant function ≥32, is the most severe form of alcohol-induced liver disease and is associated with a 1-month mortality rate of around 30%. Corticosteroid treatment remains the only therapeutic option that improves short-term survival. Infectious complications, occurring in approximately 50% of patients, are the main causes of death...
متن کاملEarly liver transplantation for severe alcoholic hepatitis.
BACKGROUND A 6-month abstinence from alcohol is usually required before patients with severe alcoholic hepatitis are considered for liver transplantation. Patients whose hepatitis is not responding to medical therapy have a 6-month survival rate of approximately 30%. Since most alcoholic hepatitis deaths occur within 2 months, early liver transplantation is attractive but controversial. METHO...
متن کاملSevere Alcoholic Hepatitis Effectively Treated with Vitamin E as an Add-on to Corticosteroids
A 49-year-old woman with a history of heavy alcohol drinking was admitted to our hospital due to jaundice and abdominal distention. A blood test showed leukophilia, mild hypoalbuminemia, hyperbilirubinemia, hepatobiliary injury and coagulopathy. Image studies showed an extremely enlarged fatty liver and splenomegaly. The Japan alcoholic hepatitis score and Maddrey's discriminant function were 1...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Gut
سال: 2011
ISSN: 0017-5749
DOI: 10.1136/gut.2011.239301.491